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What is Cissus Q (Cissus quadrangularis)?
Cissus Q is a herbal supplement derived from the plant Cissus quadrangularis, a vine native to Africa and parts of Asia, widely used in Ayurvedic and traditional African medicine. Known as "Veldt Grape" or "Bone Setter," Cissus is rich in ketosterones, quercetin, beta-sitosterol, and vitamin C, which contribute to its anti-inflammatory, anabolic, and antioxidant effects. A 500mg capsule of Cissus Q typically contains a standardized extract of the stem, formulated to support bone health, metabolic function, joint repair, and weight management.
Key Benefits of Cissus Q
| Health Benefit | Description |
|---|---|
| Bone Healing & Strength | Traditionally used to accelerate bone fracture healing and increase bone mineral density (Udupa et al., 1961). |
| Joint and Tendon Support | Reduces joint pain, stiffness, and inflammation in arthritis or sports injuries (Oben et al., 2006). |
| Anti-inflammatory Properties | Inhibits pro-inflammatory markers (e.g., COX-2), useful for managing osteoarthritis and chronic pain. |
| Antioxidant Defense | Contains flavonoids and vitamin C that neutralize oxidative stress and support tissue repair. |
| Weight Management | May help reduce body fat, waist circumference, and control appetite through modulation of cortisol (Oben et al., 2007). |
| Metabolic Support | Shown to improve blood glucose and lipid profiles in people with metabolic syndrome or type 2 diabetes. |
| Stress and Cortisol Balance | Adaptogenic effects may help reduce cortisol levels and improve mood under physical or emotional stress. |
Recommended Dosage
| Form | Dosage Range | Notes |
|---|---|---|
| Capsules (Standardized 500mg) | 500–1,000 mg daily | Often taken once or twice daily; ideally with meals for absorption. |
| Extract (10:1 or 20:1) | 250–500 mg per day | More potent extracts require lower dosages. |
| Powdered Stem | 2–3 grams per day | Traditional format; often mixed with water or taken with ghee or honey. |
Best taken: With meals, morning or after workouts for joint recovery or metabolism support.
⚠️ Precautions & Side Effects
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Generally well-tolerated, especially in short- to medium-term use.
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Mild side effects may include dry mouth, gas, or nausea in sensitive individuals.
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May lower blood glucose and interact with diabetes medications—monitor levels accordingly.
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Not recommended during pregnancy or breastfeeding due to insufficient safety data.
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Caution advised for people on blood pressure medications, as Cissus may lower blood pressure.
Always consult a qualified healthcare professional before starting Cissus Q, particularly if you are being treated for metabolic, endocrine, or orthopedic conditions.
References
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Udupa, K. N. et al. (1961). "The effect of Cissus quadrangularis in accelerating fracture healing." Indian Journal of Medical Research.
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Oben, J. E. et al. (2006). "Cissus quadrangularis induces a reduction in weight and improves metabolic syndrome markers in obese individuals." Lipids in Health and Disease.
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Oben, J. E. et al. (2007). "Cissus quadrangularis supplementation in a population of overweight and obese individuals: a placebo-controlled, double-blind study." Journal of Alternative and Complementary Medicine.
